Table 2.
Plaque sizes and reactivity of parent and mutant strains of Venezuelan equine encephalitis virus with serotype-specific monoclonal antibodies
| Virus strain | Plaque size, mm |
Monoclonal antibody number (serotype specificity) |
|||
|---|---|---|---|---|---|
| Mean | SD | 1A4D-1 (all VEEV) | 1A1B-9(enzootic, serotype ID/IE) | 1A3A-5(epidemic, serotype IAB/IC) | |
| ZPC738 | 4.05* | 0.39 | Positive | Positive | Negative |
| ZPC738/R193 | 3.60* | 0.33 | Positive | Positive | Negative |
| ZPC738/R213 | 3.81* | 0.33 | Positive | Negative | Positive |
| ZPC738/R193/R213 | 1.94† | 0.26 | Positive | Negative | Positive |
| SH3 | 1.74† | 0.29 | Positive | Negative | Positive |
Reactivity with a 1:400 dilution of each antibody as described by Roehrig et al. (36).
*Significantly different mean plaque size (ANOVA; P < 0.05) from epidemic, serotype IC strain SH3.
†Significantly different mean plaque size (ANOVA; P < 0.05) from enzootic, serotype ID strain ZPC738.