Fig. 6.

The transgene ΔNIκBα protects mice from MLDS-induced diabetes. (A) Percentage of hyperglycemic mice in untreated (bold line, n = 25), Dox-treated (dashed line, n = 26) (P < 0.05 by using Fisher's exact test and comparing percent diabetic mice in each group) and animals where Dox was administered 1 day after the last injection of STZ (n = 24, dotted line). (B) MLDS-induced diabetes presented as average blood glucose (mg/dl) from day 10. Blood glucose levels were significantly lower in the STZ-injected mice treated with Dox simultaneously (Dox + STZ; *, P < 0.01) or 1 day after the last injection (Dox after STZ; **, P = 0.042) as compared with that in untreated mice (STZ), using Student's t test.