Figure 4.

The effect of recurrent IPSPs on mitral cell firing. (A) The amplitude of the in vitro recurrent IPSP is unaffected by changing the duration of current step from 200 ms to 1 s. APs are clipped. (B) In vitro, the number of APs elicited by a 100-ms current step of a given amplitude is shown for control conditions and in the presence of bicuculline (20–40 μM). (C) (Left) Application of bicuculline in vitro resulted in prolonged depolarization and AP firing after termination of current injection. The depolarization was blocked by addition of APV (25 μM) and NBQX (10 μM). (Right) Average traces show the bicuculline-, APV-, and NBQX- (or CNQX-) sensitive components of the response obtained by digital subtraction (APs are blanked).