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. 2006 Apr 10;103(16):6212–6217. doi: 10.1073/pnas.0601700103

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© 2006 by The National Academy of Sciences of the USA

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Fig. 2. — Abnormal development of the central nervous system in UBR1^−/−UBR2^−/− embryos. (A and B) Transverse sections of ED10.5 UBR1^−/−UBR2^−/− (B) and littermate UBR1^+/−UBR2^+/− control (A) embryos stained for neurofilaments. (C–F) Hematoxylin/eosin-stained transverse sections of UBR1^−/−UBR2^−/− embryos (D and F) and littermate control embryos (wild type in C; UBR1^+/−UBR2^+/− in E) at ED10.5 (C and D) and ED11.5 (E and F). (G and H) Dorsal views of ED11.5 UBR1^−/−UBR2^−/− (H) and control (UBR1^+/+UBR2^+/−) (G) embryos. drg, dorsal root ganglion; mt, motor neuron; nt, neural tube; SC, spinal cord; FB, forebrain; HB, hindbrain. Asterisk and arrowheads in H mark the swollen pericardial sac and kinked neural tube, respectively. (Scale bars: 200 μm.)