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. 2006 Apr 10;103(16):6212–6217. doi: 10.1073/pnas.0601700103

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© 2006 by The National Academy of Sciences of the USA

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Fig. 5. — Impaired cardiovascular development in UBR1^−/−UBR2^−/− embryos. (A and B) Lateral views of ED10.5 UBR1^−/−UBR2^−/− (B) and littermate UBR1^+/+ UBR2^+/− control (A) embryos. Markings are as follows: arrow, abnormal heart morphology; asterisk, swollen pericardial sac; arrowhead, hemorrhage. (C and D) Hematoxylin/eosin-stained transverse sections of ED10.5 UBR1^−/−UBR2^−/− (D) and littermate wild-type control (C) hearts. Markings are as follows: asterisk, swollen pericardial space; arrowheads, ventricular wall; arrows, sites of septum formation in wild-type (but not in UBR1^−/−UBR2^−/−) embryos. RA, right atrium; LA, left atrium; RV; right ventricle; LV, left ventricle. (E and F) PECAM-stained ED10.5 UBR1^−/−UBR2^−/− (F) and UBR1^+/−UBR2^+/− (E) yolk sacs. Arrowheads in F indicate some of the differences in the branching patterns relative to wild-type embryos. (G and H) PECAM-stained ED10.5 UBR1^−/−UBR2^−/− (H) and UBR1^+/−UBR2^+/− (G) whole embryos. Arrowheads mark the intracranial artery. (Scale bars: 100 μm.)