Table 1.
Clinical course of recipient mice after transplantation
Characteristic | C/EBPαpos + bcr/abl | C/EBPα−/− + bcr/abl |
---|---|---|
Survival, days (median)* | 22–169 (26) | 20–157 (26) |
Spleen weight, mg (median)* | 330–750 (517) | 100–1000 (465) |
WBC per μl (median)* | 18,000–230,000 (82,000) | 7,300–71,000 (24,500) |
Hemoglobin, g/dl (median)* | 11–14.8 (13.2) | 10.2–18.5 (16.6) |
Blasts† | 0.4 ± 0.4 | 8.6 ± 3.8§ |
Myelocytes†‡ | 2.5 ± 0.7 | 0.3 ± 0.5§ |
Neutrophils† | 64.7 ± 16.2 | 4.8 ± 5.7§ |
Eosinophils† | 0.7 ± 0.7 | 0.0 ± 0.0 |
Lymphocytes† | 26 ± 16.2 | 17 ± 21.5 |
Monocytes† | 4.2 ± 1.6 | 1.6 ± 0.9§ |
Normoblasts, erythroblasts† | 1.4 ± 1.5 | 66.5 ± 31.4§ |
More than 80% of the mice were killed within 60 days after transplantation. The mouse with acute lymphocytic leukemia (recipient of C/EBPα+/− + bcr/abl) is not included. For the differential counts, the percentage of each type of the nucleated blood cells ± SD is given.
*n = 7 for C/EBPαpos and n = 9 for C/EBPα−/− transplants.
†n = 4 for C/EBPαpos and n = 5 for C/EBPα−/− transplants.
‡Myelocytes include promyelocytes, myelocytes, and metamyelocytes.
§P < 0.05.