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Defective MAPK signaling downstream of ITAM-based NK cell receptors. (A) ERK activation after stimulation of WT and CD45−/− NK cells with anti-NK1.1 mAb. (B) ERK activation after stimulation with anti-NKG2D mAb or with plate-bound mouse IgG2a to activate via CD16. (C) JNK activation after stimulation with anti-NK1.1 mAb. Two exposures (short and long) are shown. (D) p38 activation after stimulation with anti-NK1.1 mAb. Data are representative of two to seven experiments.
