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. 2006 Apr 24;103(18):7036–7041. doi: 10.1073/pnas.0509166103

Fig. 4.

Fig. 4

Human SH3 domains with the potential to bind to P4 peptide and their blockage by UCS15A. Membrane filters spotted with various SH3 domains were incubated with biotinylated P4 peptide in the absence or presence of UCS15A. Binding strengths of the SH3 domains were calculated by normalizing the binding of P4 and cortactin SH3 as 100% and are indicated as colored squares. The SH3 domains we examined that exhibited <25% of binding compared with that of P4 and cortactin SH3 are as follows: ABL2, ABL2B, Amphiphysin, ARGBP2-D1, ARGBP2-D2, ARGBP2-D3, ARH6, ARHGEF9, ARHGEF16, BAIAP2, BCA1, BIN1, BLK, BMX, BPAG1, BZRAP1-D1, CACNβ2, CCBA, CRK-D1, CRKL-D1, CRKL-D2, CSK, CSKP, CXorf9-D1, DDEF2, DKFZp434D0215-D3, DKFZp434D0215-D4, DKFZP434D146, DLG2, EMP55, EPS8, FGR, FYB-D1, FYB-D2, GRAF, GRAP-D1, GRB2L-D1, GRB2-D1, GRB2-D2, HIP-55, HS1, ITK, ITSN-D1, ITSN-D2, ITSN-D3, ITSN (2)-D1, ITSN (2)-D2, JIP1, JIP2, KIAA0418-D3, KIAA0418-D5, KIAA0456, KIAA0554, KIAA0790, KIAA1139, KIAA1249, LASP1, M3KA, MIA, MLPK3, MY1E, MY7A, NCF1-D1, NCF1-D2, NCF4, NCK1-D1, NCK1-D3, NCK2-D1, NCK2-D2, NCK2-D3, NEB1, Nebulin, NE-DLG, NOF2-D1, OTOR, PI3a, PI3b, PIG2, PLCγ, PPP1R13B, PRMT2, PSD95, RHG4, RIZ, SH3GL3, SH31, SJHUA, SLA, SORBS-D3, SP93, SPCN, SPIN90, SRGAP2, STAC, STAM2, TIM, TRIO, TRIO (2), TRIP10, TXK, UAS3, VAV-D1, VAV-D2, VAV2-D1, VAV2-D2, VAV3-D1, VINE-D1, VINE-D2, YES1, and ZO2.