Table 1.
Summary of comparisons between four hAPP transgenic mouse lines
| Measurement | PDAPP(J9) | PDAPP D664A(B21) | PDAPP(J20) | PDAPP D664A(B254) |
|---|---|---|---|---|
| Transgene | APPSw,ln | APPSw,ln D664A | APPSw,ln | APPSw,ln D664A |
| APP expression, OD/mm2 | 76 | 103 | 151 | 187 |
| Aβ (ELISA), rank order | Fourth | Third | Second | First |
| Aβ plaques, rank order | Third | Second | First | ND |
| Brain weight (vs. control) | Normal | Normal | Normal | Normal |
| HSPD | Decreased* | Normal | Decreased | Normal |
| Dentate gyral volume | Decreased | Normal | Decreased | Normal |
| fEPSP (CA3→CA1) | (Abnormal)† | Normal | Abnormal | ND |
| Spatial memory | ND | Normal | Impaired | Normal |
| Working memory | ND | ND | Impaired | Normal |
| Novel object exploration | ND | ND | Abnormal | Normal |
| Neurogenesis (SGZ) | Increased‡ | Normal | Increased‡ | ND |
ND, not determined.
*HSPDs in transgenic PDAPP(J9) mice have been shown to be decreased in refs. 2 and 9. In the present study, synaptic densities in transgenic PDAPP (J9) animals were reduced by 30% by 9-mo but reached statistical significance only at 12 mo.
†fEPSPs in transgenic PDAPP(J9) mice have been shown to be impaired (2), and improvement in PDAPP(D664A)B21 was reported in abstract form (10,11).
‡Transgenic and nontransgenic PDAPP(J9) and PDAPP(J20) mice were combined.