Fig. 5.
Brain Y5R occupancy and drug exposure levels after oral administration of the Y5R antagonist. (A and B) Brain Y5R occupancy in lean C57BL/6J mice (A) and other obesity models (B). (C and D) Plasma concentration of the Y5R antagonist. In A, filled diamonds, asterisks, and open circles represent 10, 30, and 100 mg/kg, respectively, in lean mice. In B and C, filled circles represent mice with DIO, open circles represent lean mice, open triangles represent Leprdb/db mice, filled triangles represent Leprdb/db mice on an MHF diet, and open diamonds represent Zucker fatty rats. In D, open squares represent wild-type mice, and filled squares represent Y5R KO mice. Data are expressed as means ± SD (n = 3).