Table 1.

Body weight change during each crossover dosing arm

Mouse	Body weight change, g
	First arm (days 1–19)	Second arm (days 20–33)	Third arm (days 34–46)
Wild type
Vehicle	3.60 ± 0.31	3.18 ± 0.37	1.75 ± 0.54
Y5R antagonist	1.62 ± 0.61*	0.05 ± 0.32†	−1.06 ± 0.30†
Y5R KO
Vehicle	3.12 ± 0.49	2.22 ± 0.67	2.32 ± 0.40
Y5R antagonist	3.68 ± 0.38	1.15 ± 0.40	1.42 ± 0.32

Data represent mean ± SE of four to six animals.

*, P < 0.05;

^†, P < 0.01 (compared with vehicle-treated group; Student's t test).