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. 2006 May 11;116(6):1494–1505. doi: 10.1172/JCI26498

Figure 6. Metabolic characteristics of MCP-1 KO mice fed a high-fat diet.

Figure 6

(A) Metabolic parameters of mice fed a high-fat diet from 12 to 24 weeks of age. Data are means ± SEM (body weight, n = 5 [WT], 9 [KO]; food intake, n = 4; plasma glucose, n = 5; serum FFA, n = 6 [WT], 5 [KO]; plasma insulin, n = 7 [WT], 6 [KO]; serum triglyceride, n = 7 [WT], 6 [KO]; serum total cholesterol, n = 6 [WT], 5 [KO]; serum adiponectin, n = 7 [WT], 5 [KO]). (B) Plasma glucose level during insulin (upper panel) and glucose (lower panel) tolerance tests in mice fed a high-fat diet from 12 to 24 weeks of age. Data are mean ± SEM (n = 6). (C) Hyperinsulinemic-euglycemic clamp analysis in mice fed a high-fat diet from 12 to 28 weeks of age. Data are mean ± SEM (WT, n = 6; KO, n = 5). (D) Hepatic triglyceride content of mice fed a high-fat diet from 12 to 28 weeks of age. Data are mean ± SEM (n = 5). (E) Quantitation by Northern blot of the hepatic abundance of PEPCK, G6Pase, and SREBP-1c mRNAs in mice after hyperinsulinemic-euglycemic clamp analysis. Data (mean ± SEM; n = 5) were expressed relative to the corresponding WT value. *P < 0.05, **P < 0.01 versus WT.