TABLE 3.
Changes in Select Proteinase, Growth Factor, and Structural Genes in Diabetic Corneas as Revealed by Gene Microarray Analysis
| Gene | Diabetic*/Normal (P) | Possible Role |
|---|---|---|
| MMP-1⇓ | 0.50 (0.0001) | Proteolysis |
| MMP-2⇓ | 0.40 (<0.0001) | Proteolysis |
| MMP-7⇓ | 0.42 (<0.0001) | Proteolysis |
| MMP-11⇓ | 0.35 (<0.0001) | Proteolysis |
| MMP-13⇓ | 0.43 (0.0002) | Proteolysis |
| TIMP-4⇓ | 0.44 (<0.0001) | Proteolysis |
| Cathepsin F⇑ | 3.70 (<0.0001) | Proteolysis |
| Cystatin F⇓ | 0.37 (<0.0001) | Proteolysis |
| Cystatin S⇓ | 0.35 (<0.0001) | Proteolysis |
| HGF⇑ | 1.92 (0.006) | Growth factor |
| c-met proto-oncogene ⇓ | 0.76 (0.014) | Growth factor receptor |
| FGF-3⇓ | 0.38 (<0.0001) | Growth factor |
| FGFR3⇓ | 0.28 (<0.0001) | Growth factor receptor |
| Thymosin β4⇓ | 0.35 (<0.0001) | Apoptosis, cell migration |
| IL27⇑ | 4.57 (<0.0001) | Inflammatory cytokine |
| Type VI collagen α3 chain⇑ | 3.50 (0.0004) | Structural |
| Laminin α4 chain⇓ | 0.47 (<0.0001) | Structural |
*
Because the expression levels of all select genes data in diabetic and DR groups were similar, combined data are presented. Arrows show changes in diabetic and normal corneas (⇑, increase; ⇓, decrease).