. Author manuscript; available in PMC: 2006 May 10.

Published in final edited form as: Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3604–3615. doi: 10.1167/iovs.04-1507

TABLE 4.

Marker Distribution in Human Corneas by Immunostaining

Protein	Ex Vivo Normal	Ex Vivo DR	OC Normal	OC DR
Cathepsin F⇑	2/15 positive^*	6/11 positive	0/11 positive^*	4/8 positive
Cathepsin B	5/12 positive	8/11 positive	2/4 positive	5/5 positive
Cathepsin H	7/10 positive	11/11 positive	5/11 positive	6/8 positive
Cathepsin L	2/12 positive	6/11 positive	2/4 positive	4/5 positive
Laminin α4⇓	10/10 intact^*	2/10 intact	5/7 intact^*	1/8 intact
TIMP-4⇓	7/10 positive^*	1/10 positive	7/10 positive^*	0/8 positive
HGF⇑	4/15 positive^*	8/11 positive	0/11 positive^*	7/8 positive
c-met⇓	15/15 strong^*	6/11 strong	8/11 strong	3/8 strong
FGF-3⇓	11/11 positive^*	7/12 positive	11/11 positive^*	3/7 positive
FGFR3⇓	11/11 positive^*	6/11 positive	9/11 positive^*	2/7 positive
Thymosin β₄⇓	5/11 strong^*	0/11 strong	8/11 positive^*	0/7 positive

The first number in each pair is the number of cases with a specific pattern (eg, positive, strong); the second number represents the total number of cases analyzed. OC, organ culture; intact, continuous staining of epithelial BM;

P < .05 vs DR; arrows show changes in DR and normal corneas (a, increase; s, decrease).