Table 1.

Activating effect of agonists on Lag Time.

Assay System N-PRP plus	Lag Time (minutes) mean ± SD
	B	C	D	E	F	G	H
	Saline	rFVIIa 5 μg/mL	p value B vs C	rFVIIa 2.6 μg/mL	P value B vs E	rFVIIa 0.5 μg/mL	p value B vs G
1. Saline	17.1 ± 5.1	7.9 ± 2.1	<0.001	8.2 ± 2.4	<0.001	9.0 ± 1.9	<0.001
2. ADP 2 μM	11.5 ± 3.0	7.2 ± 2.0	<0.001	7.6 ± 1.6	<0.001	8.1 ± 2.0	<0.001
3. Col 0.5 μg/mL	11.9 ± 3.1	7.0 ± 2.8	<0.001	7.9 ± 2.8	<0.001	8.4 ± 2.9	<0.001
4. AA 0.625 mmol/L	8.4 ± 2.0	5.9 ± 1.2	<0.05	6.2 ± 1.3	<0.05	6.8 ± 1.3	<0.05
5. AA 0.125 mmol/L	9.5 ± 2.7	6.5 ± 1.5	<0.05	7.0 ± 1.8	<0.05	7.3 ± 1.7	<0.05

Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.

Column B:1 vs 2 to 5 p < 0.01 Column C: 1 vs 4 and 5 p < 0.01; Column E. 1 vs 4 and 5 p < 0.005 for both; Column G. 1 vs 4 and 5 p < 0.01 for both.