Table 4.

Activating effect of agonists on Area under the curve (AUCo→ _35min ).

Assay System N-PRP plus	AUC (nmol/L) mean ± SD
	B	C	D	E	F	G	H
	Saline	rFVIIa 5 μg/mL	p value B vs C	rFVIIa 2.6 μg/mL	P value B vs E	rFVIIa 0.5 μg/mL	P value B vs G
1. Saline	934 ± 431	1770 ± 411	<0.001	1661 ± 363	<0.001	1850 ± 327	<0.001
2. ADP 2 μM	1523 ± 364	1873 ± 366	<0.05	1773 ± 349	<0.05	2078 ± 437	<0.01
3. Col 0.5 μg/mL	1430 ± 470	1883 ± 433	<0.01	1766 ± 384	<0.05	2032 ± 502	<0.01
4. AA 0.625 mmol/L	1520 ± 373	1711 ± 410	NS	1726 ± 404	NS	1934 ± 408	<0.01
5. AA 0.125 mmol/L	1754 ± 374	1991 ± 372	NS	1872 ± 355	NS	2115 ± 403	<0.01

Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.

Column B:1 vs 2 to 5 p < 0.01 for all. Column G: 1 vs 5 p < 0.01