Figure 10.

Effect of iberiotoxin on FSK-induced airway relaxation. (A) Airway contraction in response to MCh (200 nM), FSK (10 μM) and IbTX (50 nM). IbTX greatly enhanced the relaxation induced by FSK to fully relax the airway. Representative traces of 6 experiments from 3 mice. (B) Changes in intracellular Ca²⁺ signaling and (C) the frequency of Ca²⁺ oscillations induced by MCh (200 nM) and FSK (10 μM) followed by exposure to IbTX (50 nM). The frequency of the Ca²⁺ oscillations was further slowed by IbTX. Representative traces of 8 experiments from 5 mice.