Table 1.
Ligand-binding properties of the δ–β2, κ–β2, δ, κ, and β2 receptors
| Ligand |
Ki
|
||||||
|---|---|---|---|---|---|---|---|
| [3H]Diprenorphine
binding
|
[3H]CGP binding
|
||||||
| δβ2 | κβ2 | δ | κ | δβ2 | κβ2 | β2 | |
| CGP | >10 μM | >10 μM | >10 μM | >10 μM | 0.2 ± 0.3 nM | 0.9 ± 0.1 nM | 0.17 ± 0.03 nM |
| Isoproterenol | >10 μM | >10 μM | >10 μM | >10 μM | 1.1 ± 0.6 μM | 1.2 ± 0.1 μM | 1.17 ± 0.6 μM |
| Epinephrine | >10 μM | >10 μM | >10 μM | >10 μM | 1.2 ± 0.4 μM | 3.4 ± 0.6 μM | 3.12 ± 0.7 μM |
| DPDPE | 60 ± 6.4 nM | >10 μM | 82 ± 6.3 nM | — | >10 μM | — | >10 μM |
| U-69593 | — | 70.6 ± 6.4 nM | — | 65.7 ± 0.3 nM | — | >10 μM | >10 μM |
| nor-BNI | — | 0.7 ± 0.2 nM | — | 0.4 ± 0.3 nM | — | >10 μM | >10 μM |
Data represent means ± SEM (n = 3–7); —, not determined.