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. 2006 Apr 11;6:16. doi: 10.1186/1471-2261-6-16

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Copyright © 2006 Felty; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Antioxidant N-acetylcysteine blocks estrogen-induced DNA synthesis. Human umbilical vein endothelial cells pretreated with the antioxidant N-acetylcysteine (NAC) showed a significant reduction in E2-induced DNA synthesis. Data from three independent experiments are presented as ROS production with controls set at 100% (± SD). Values that are significantly different from E2 treatment alone (P < 0.05) are indicated with an asterisk (*). Significant increases in DNA synthesis by E2 (P < 0.05) are indicated by (#).