Fig. 7.
Model prediction of ECS width (dECS) from experimental λ and dH. (A) Cartoon depiction of models, both of which incorporate a centerline approximation for RD (shown within pore, upper right). (B) Best-fit curves for each model applied to normoxic tissue data, including TMA (14), and for TR-dex3 and TMA (16) after terminal ischemia. Best-fit parameters: cylindrical pore, normoxia: dECS = 63.8 nm, λθ=0 = 1.63, R = 0.97. Parallel plane, normoxia: dECS = 37.7 nm, λθ=0 = 1.72, R = 0.98. Cylindrical pore, ischemia: dECS = 5.7 nm, λθ=0 = 1.64. Parallel plane, ischemia: dECS = 3.2 nm, λθ=0 = 1.69.