Fig. 3.

Circumvention of adenovirus-specific immune response by microencapsulation of AdCA36lacZ. 6-8 week old BALB/c mice (5 animals/group) were immunized intranasally (i.n.) with PBS or once (1x)/twice (2x) with 1 X 10⁸ p.f.u. of HAd5, and following development of HAd5-specific antibodies animals were inoculated i.n. with a nonencapsulated (NE-Z) or encapsulated (E-Z) in alginate microspheres preparation containing 2.5 x 10⁸ p.f.u. of AdCA36lacZ. The A) lungs and B) tracheae were collected and analyzed for LacZ expression. Each point represents the mean value for five animals ± SD.