Table 1.

HAd5-specifi c neutralizing antibody response in mice inoculated with HAd5^a

		HAd5-specific neutralizing serum antibody titers
Group	Route of Inoculation	Mice primed once with HAd5	Mice primed twice with HAd5
Naive/NE-Z/i.n.	i.n.	<25
Naive/E-Z/i.n.	i.n.	<25
HAd5/NE-Z/i.n.	i.n.	400
HAd5/E-Z/i.n.	i.n.	400
HAd5-HAd5/NE-Z/i.n.	i.n.		800
HAd5-HAd5/E-Z/i.n.	i.n.		800
Naive/NE-Z/i.p.	i.p.	<25
Naive/E-Z/i.p.	i.p.	<25
HAd5/NE-Z/i.p.	i.p.	800
HAd5/E-Z/i.p.	i.p.	800
HAd5-HAd5/NE-Z/i.p.	i.p.		1600
HAd5-HAd5/E-Z/i.p.	i.p.		1600

^aSerum samples obtained from mice inoculated once (1X) or twice (2X) with HAd5 were used to detect levels of HAd5-specifi c neutralizing antibodies by virus-neutralizing assay. Neutralizing antibody titers are expressed as the highest reciprocal serum dilution resulting in reduction of virus plaque formation by at least 50%. Titers are expressed as mean value from 5 mice per group.