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Classification of trajectories in terms of secondary-structure elements by DSSP (35). The residue-wise DSSP classifications are shown for the trajectories for wtPrP (A), PrP-M205S (B), and PrP-M205R (C). As a reference, the DSSP classification of the NMR structure (3) is displayed at the left and right margins. For comparison, the classification in terms of prototypical backbone structures from Figs. 3 B, 4 B, and 5 B is indicated at the top of the DSSP plots.
