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. 2006 Mar 2;90(11):4018–4034. doi: 10.1529/biophysj.105.073569

FIGURE 4.

FIGURE 4

Mutations at the base of the selectivity filter alter spermine permeation. (Top) Typical current traces recorded during voltage pulses from −130 to +60 mV from endogenous, wild-type (ATAT/SASA), Kir3.1-A-142V/Kir3.4-T-148V (VVVV/SASA) and Kir3.1-S-166L/Kir3.4-A-172L (ATAT/LLLL) channels with K+ or spermine as the charge carrier. Currents were recorded in 90 mM extracellular K+ or 90 mM extracellular spermine. Arrows indicate zero current. (Bottom) Mean normalized current-voltage relationships for each channel with K+ or spermine as the charge carrier. Mean ± SE shown (n = 5–9). Data corrected for junction potentials.