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Interactions between Kir3.1-A-142/Kir3.4-T-148 and Kir3.1-S-166/Kir3.4-A-172 at the base of the selectivity filter. A, B, summary of the effects of combinations of mutations made at positions Kir3.1-A-142/Kir3.4-T-148 and Kir3.1-S-166/Kir3.4-A-172 on the KD (at −130 mV) of Cs+ block (A) and Rb+ current (at −130 mV; B). Means ± SE shown (n = 5–6). *p < 0.001 and ‡p < 0.002 as compared to the wild-type channel (one-way ANOVA).
