TABLE 1.

Model variables and parameters

Symbol	Meaning	Value used in shown figures	Values tested in model	Reference
Model variables
,	Position of the right and left kinetochore	Variable
	Position of the plus end of the ith right and left kMT	Variable
	Velocity of the right and left kinetochore	Variable
	Velocity of the ith right kMT	Variable
	Velocity of the ith left kMT	Variable
Model parameters
	Maximal motor force for dynein, cenpE, and depolymerization motors, respectively.	1.2 pN
		2 pN	0.1–10 pN	(40,69)
		5 pN
nd	Number of dynein, cenpE motors per micron, and depolymerization motors per MT minus end, respectively.	15
nc		5	1–50	Assumed in this article.
ndep		20
	Unloaded rate for dynein, cepnE, and depolymerization motors, respectively.	0.5 μm/s
		0.12 μm/s	0.01–1 μm/s	(40,70)
		0.05 μm/s
μ	Effective viscous drag coefficient of Drosophila chromosome	5 pN·s/μm	1–10	(42)
N	Maximum number of MT binding sites at the kt.	7–30	1–50	(2,6)
ɛ	Elastic modulus of the kt plate.	25–100 pN/μm	10–200 pN/μm	Assumed in this article.
κ	The spring constant and the rest length of cohesin bonds between sister kts.	50–100 pN/μm	10–200 pN/μm	(34)
d0		0.5 μm	0.5–2 μm
r	Distance between the corona tip and the kt plate.	0.5 μm	0.1–1 μm	(25)
ρ	Coefficient of polar ejection force intensity.	4 pN/μm2	1–10 pN/μm2	(34,36)
vg and vs	Growth and shrinkage rate of MTs.	0.25 μm/s	0.05–0.3 μm/s	(71)
fres	Rescue and catastrophe frequencies of MTs.	0.05–0.1/s	0.2–0.005/s	(58,71)
fcat		0.08–0.01/s
φ	Scaling factor for growth and shrinkage rate of MT tips in the kt.	2	1–5	Assumed in this article.
γKLP59C	Scaling factor for decrease in rescue frequency by KLP59C.	10	1–50	(44)
ϕ	Scaling factor for increase in catastrophe frequency for MT tip impinging on kt plate.	2	1–5	(45)
α	Factor for rescue frequency dependence on tension between kts.	0.45/pN	0.1–2	Assumed in this article.
β	Factor for rescue frequency dependence on polar ejection forces.	0.3/pN	0.1–2	Assumed in this article.
ζ	Factor for rescue frequency dependence on polymerization ratchet forces.	0.2–0.1/pN	0.01–1	Assumed in this article.