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. 2006 Mar 2;90(11):4119–4127. doi: 10.1529/biophysj.105.078147

FIGURE 2.

FIGURE 2

Rate of force redevelopment in skinned myocardium from WT and cMyBP-C−/−. Differences in the rate constant of force redevelopment (ktr) were expressed relative to respective peak forces. (A) The rates of force redevelopment measured in the absence of NEM-S1 from two representative skinned myocardial preparations from either WT (left trace: pCa 4.5, P/Po = 1.0, ktr = 34.7 s−1; right trace: pCa 5.8, P/Po = 0.40, ktr = 5.1 s−1) or cMyBP-C−/− (middle trace: pCa 5.8, P/Po = 0.40, ktr = 11.4 s−1). (B) The rates of force redevelopment measured in the presence of NEM-S1 from two representative skinned myocardial preparations from either WT (left trace: pCa 4.5, P/Po = 1.0, ktr = 33.0 s−1; right trace: pCa 5.8, P/Po = 0.55, ktr = 16.1 s−1) or cMyBP-C−/− (middle trace: pCa 5.8, P/Po = 0.57, ktr = 23.5 s−1).