C denotes cyclophosphamide, A doxorubicin, F fluorouracil, and P paclitaxel. Study 8541 had three treatment arms, with doses of C, A and F in proportion to the dose of doxorubicin that is shown (in milligrams per square meter of body surface area). Study 9344 had a 3 by 2 factorial design, with randomization to one of 3 doses of A with a second randomization to 4 cycles of paclitaxel or not. Study 9741 had a 2 by 2 factorial design, with patients being randomized to biweekly vs triweekly schedules and separately to concurrent AC followed by P vs sequential A followed by P then C.