FIG. 1.
rAls1p-N vaccine improves survival of outbred, CD1 mice from hematogenously disseminated candidiasis. (A) CD1 mice (n = 8 per group) were vaccinated subcutaneously with rAls1p-N (20 μg) plus CFA or with CFA alone and infected via the tail vein with C. albicans SC5314 14 days after the boost. (B) CD1 mice (n = 8 per group) were vaccinated subcutaneously with rAls1p-N at various doses with alum or with alum alone and infected via the tail vein with C. albicans SC5314 14 days after the boost. The inoculum for panels A and B was 5 × 105 blastospores. *, P < 0.05 versus adjuvant control by log rank test.