FIG. 3.

rAls1p-N vaccine reduces tissue fungal burden in BALB/c mice infected with several non-C. albicans strains of Candida. BALB/c mice (n = 5 per group) were vaccinated with CFA or CFA plus rAls1p-N (20 μg) and infected via the tail vein with C. glabrata, C. krusei, C. parapsilosis, or C. tropicalis. Infectious inocula are shown in parentheses below the species names. Kidney fungal burden was determined on day 5 postinfection. The y axis reflects the lower limit of detection of the assay. *, P < 0.05 versus adjuvant control by nonparametric Steel test for multiple comparisons.