TABLE 1.
Analysis of serum and lung wash samples following intratracheal administration of MAbs 7.3 and F1-04-A-G1
| Mouse | Treatmenta | Amt of MAb (ng ml−1)b
|
|||
|---|---|---|---|---|---|
| 7.3
|
F1-04-A-G1
|
||||
| Serum | Lung wash | Serum | Lung wash | ||
| 1 | PBS | ND | ND | ND | ND |
| 2 | PBS | ND | ND | ND | ND |
| 3 | 15.5 μg MAb | 1,631 | ND | 882 | ND |
| 4 | 15.5 μg MAb | 18 | 5 | 77 | 20 |
| 5 | 15.5 μg MAb | 5 | 10 | 43 | 30 |
| 6 | 15.5 μg MAb | 284 | ND | 377 | ND |
| 7 | 77.5 μg MAb | 586 | ND | 872 | ND |
| 8 | 77.5 μg MAb | 671 | ND | 634 | ND |
a
MAb 7.3 (15.5 or 77.5 μg in 50 μl PBS) and MAb F1-04-A-G1 (15.5 or 77.5 μg in 50 μl PBS) or PBS was delivered as a spray to the lungs of anesthetized mice by means of the PenCentuary device.
b
Amount of MAb 7.3 or MAb F1-04-A-G1 in mouse serum and lung wash samples 2 h posttreatment. ND, none detected.