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Protection against S. aureus strain Reynolds with IgG1 MAbs (12 mice per group). (A) A 600-μg volume of each MAb was administered 4 h before bacterial challenge. (B) A 300-μg volume of each MAb was administered 4 h before bacterial challenge. Challenge dose, 2.5 × 108 CFU/mouse; *, P value less than 0.05 compared to IgG1 control MAb.
