TABLE 4.
MAb | 50% Maximal binding (ng/ml)a | 95% Confidence interval (ng/ml) | r2 goodness of fit |
---|---|---|---|
F598 | 17.66 | 16.28-19.15 | 0.9997 |
F628 | 84.75 | 76.38-94.03 | 0.9994 |
F630 | 1051 | 913.4-1209 | 1.0 |
Determined by nonlinear regression of data for IgG1 MAb binding to PNAG (as shown in figure 1A) by use of a sigmoidal curve-fitting function for a variable slope and plotting the log10 concentration of the MAb versus percent maximal binding.