TABLE 1.
Bactericidal activities of monoclonal antibodies
| Monoclonal antibody
|
Bactericidal activity (μg/ml)a
|
|||
|---|---|---|---|---|
| Nameb | Specificity | Origin | Infant rat complement | Human complement |
| Nmb735 (IgG2a) | Group B PS | Mouse | 0.027 | 0.08 |
| MN12H2 (IgG2a) | P1.16 PorA | Mouse | 0.027 | 0.08 |
| hIgG1 | P1.16 PorA | Mouse-human chimera | 0.25 | 0.74 |
| hIgG2 | P1.16 PorA | Mouse-human chimera | 0.74 | 2.2 |
| hIgG3 | P1.16 PorA | Mouse-human chimera | 0.25 | 0.74 |
| hIgG4 | P1.16 PorA | Mouse-human chimera | >20 | >20 |
a
Lowest antibody concentration needed for ≥90% killing of strain 44/76-SL (B:15:P1.7,16) bacteria in the presence of infant rat complement (HsdBrlHan:WIST) or human complement. The complement source (20% infant rat serum or human serum) did not show significant killing alone.
b
hIgG1 to hIgG4, P1.16 PorA-specific human IgG1 to IgG4 isotypes derived from MN12H2.