TABLE 1.
Response to experimental inoculation of H. ducreyi 35000HP, 35000HPncaA, and 35000HPncaA merodiploid in pigs
| Strain |
H. ducreyi CFU per lesion biopsya at day p.i.:
|
% H. ducreyi-positive biopsiesb at day p.i.:
|
||
|---|---|---|---|---|
| 2 | 7 | 2 | 7 | |
| 35000HP | 161.0 (90.5-497.4) | 146.8 (111.2-320.8) | 60.3 (30.9-75.7) | 72.9 (57.5-96.8) |
| 35000HPncaA | 30.4 (19.5-82.3)c | 6.1 (2.2-28.6)c | 56.4 (31.6-68.7) | 20.0 (17.1-61.7)c |
| 35000HPncaA merodiploid | 280.9 (181.0-1390.2) | 320.3 (148.3-1080.7) | 70.0 (24.9-85.4) | 75.0 (64.3-95.7) |
a
Values indicate the observed mean CFU per biopsy, with 95% confidence intervals in parentheses, as modeled by poisson regression and GEE adjustment to account for variability between pigs.
b
Values indicate the observed mean proportion of biopsies harboring viable H. ducreyi, with 95% confidence intervals in parentheses, as modeled by logistic regression and GEE adjustment.
c
Significantly different (P < 0.0001) from values for wild-type or merodiploid lesions on same day postinoculation.