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. 2001 Jan 9;98(2):491–496. doi: 10.1073/pnas.98.2.491

Figure 7.

Figure 7

Hypothetical diagram depicting the regulation of ANK220 by Sig-1R and associated ligands. In the presence of a Sig-1R agonist, such as (+)PTZ, cocaine, or certain steroids, the Sig-1R/ankyrin B complex dissociates from IP3R-3 on the ER perhaps as a transport vesicle. As a result, IP3 binding to IP3R-3 increases and the Ca2+ efflux is enhanced. In the presence of the putative Sig-1R antagonist, NE-100, Sig-1R is dissociated from ANK220, which remains coupled to IP3R on the ER.