Figure 7.

Hypothetical diagram depicting the regulation of ANK220 by Sig-1R and associated ligands. In the presence of a Sig-1R agonist, such as (+)PTZ, cocaine, or certain steroids, the Sig-1R/ankyrin B complex dissociates from IP₃R-3 on the ER perhaps as a transport vesicle. As a result, IP₃ binding to IP₃R-3 increases and the Ca²⁺ efflux is enhanced. In the presence of the putative Sig-1R antagonist, NE-100, Sig-1R is dissociated from ANK220, which remains coupled to IP₃R on the ER.