Fig. 2.

A schematic summary of the neuronal differentiation cascade in the DG. QNPs generate, through asymmetric divisions, the ANPs that, after several rounds of symmetric divisions, exit the cell cycle within 1–3 days and become postmitotic NB1 cells. Within next 15–21 days, NB1 cells mature into NB2 and then into IN with apical processes and basal axons and the soma located in the GCL. After an additional 10–15 days, INs acquire the characteristics of mature granule neurons, develop extensive branching, and send long axonal processes, forming the mossy fiber.