Fig. 5.

Fluoxetine increases proliferation of ANP cells in the DG. (A–D) Treatment with fluoxetine does not change the number of dividing (BrdU-labeled) QNPs (A) but increases division of ANPs (B). The fraction of BrdU-labeled QNP or ANP cells among total QNP or ANP cells, respectively, remains the same (C and D). V, vehicle; F, fluoxetine. n = 6 per group. ∗, P < 0.05. (E–H) A cluster of BrdU-positive ANP cells between two QNPs in the DG of a fluoxetine-treated animal. QNP cells are identified by the presence of GFAP-positive processes. CFPnuc is shown in green (F), BrdU in red (G), and GFAP in blue (H). (Scale bar: 5 μm.)