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. 2006 May;173(1):111–130. doi: 10.1534/genetics.105.054007

Figure 7.

Figure 7.

Loss of PDE-4 function does not significantly affect levamisole or aldicarb sensitivity. (A) Loss of PDE-4 function does not affect the postsynaptic body-wall muscle response to the acetylcholine receptor agonist levamisole. The percentage of animals that are paralyzed over a 60-min time course of exposure to 800 μm levamisole on solid media plates is shown. unc-29(x29), included as a negative control, lacks functional levamisole ACh receptors (Gally et al. 2004). Error bars represent the standard errors of the mean for populations of 20 animals at each time point. (B) Loss of PDE-4 function does not significantly affect sensitivity to the acetylcholinesterase inhibitor aldicarb. The percentage of animals that are paralyzed over a 90-min time course of exposure to 2 mm aldicarb on solid media plates is shown. pde-4(ce268) appears slightly hypersensitive to aldicarb only at the 50-min time point, but this is not statistically significant (P = 0.13 using the unpaired t-test with Welch correction). The unc-10 null mutant md1117 is shown as a positive control for aldicarb resistance (Koushika et al. 2001). Error bars represent the standard errors of the mean for populations of 20 animals at each time point.