TABLE 2.
Summary of location and effects of detected QTL for refractoriness against Plasmodium falciparum infection in Anopheles gambiae isofemale families
| Isofemale family
|
||||||
|---|---|---|---|---|---|---|
| Chromosome | Statistic | 101 | 102 | 201 | 202 | 203 |
| 2 | LOD score | 2.26* | 0.73 | 2.41** | 1.69* | 0.90 |
| Location (cM)a | 44 | 20 | 44 | 51 | 46 | |
| Additive effectb | −2.12 (0.62) | 0.31 (0.63) | −1.93 (0.62) | −0.74 (0.28) | 0.54 (0.49) | |
| Dominance effectc | −0.78 (0.95) | 0.54 (1.2) | −1.25 (0.95) | 0.45 (0.41) | 0.36 (0.19) | |
| Variance (%)d | 10.2 | 1.0 | 11.0 | 8.3 | 1.3 | |
| 3 | LOD score | 1.97* | 0.79 | 0.85 | 0.81 | 3.53** |
| Location (cM)a | 6 | 36 | 67 | 48 | 5 | |
| Additive effectb | −1.24 (0.86) | 0.09 (0.14) | −0.02 (0.26) | 0.16 (0.73) | −1.6 (0.95) | |
| Dominance effectc | −2.42 (1.03) | 0.13 (0.61) | 0.75 (0.38) | 0.05 (0.12) | −3.23 (1.02) | |
| Variance (%)d | 9.1 | 2.1 | 4.1 | 3.8 | 14.2 | |
*
P < 0.05; ** P < 0.01.
a
Location (in centimorgans) was estimated at the position of maximum LOD score.
b
The negative additive effect indicates genetic effects for refractoriness. Numbers in parentheses are SE.
c
The negative dominance effect suggests that heterozygotes had lower parasite intensity when compared with homozygotes. Numbers in parentheses are SE.
d
Variance is the proportion of phenotypic variance explained by each QTL.