TABLE 1.
Genotype | Average inductiona | % Muvb | n |
---|---|---|---|
+/+ | 3.0 | 0 | Many |
let-60(n1046gf) | 3.9 | 80 | 45 |
let-60(n1046gf); sem-5(n2195)G201R | 3.2 | 18 | 40 |
let-60(n1046gf); soc-1(n1789) | 3.5 | 53 | 36 |
ptp-2(op194); let-60(n1046gf) | 3.4 | 56 | 41 |
soc-1(n1789) and ptp-2(op194) are null mutations. ptp-2 was linked to unc-4(e120). Suppression of let-60(gf) by sem-5(n2195), soc-1(0), and ptp-2(0) was significant (Fisher's exact test P < 0.05). A significantly greater number of animals with more than three cells was induced in let-60ras(gf); soc-1(0) and ptp-2(0); let-60ras(gf) relative to let-60ras(gf); sem-5(n2195) animals (Fisher's exact test P < 0.05). There was no difference between let-60ras(gf); soc-1(0) and ptp-2(0); let-60ras(gf) (Fisher's exact test P = 0.82).
Total number of VPCs adopting a vulval cell fate divided by the number of animals scored.
Proportion of animals having more than three VPCs induced.