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Coordinate regulation of genes involved in macrophage sterol efflux by LXRs. Peritoneal macrophages were isolated from wild-type or Lxrα/β−/− mice and incubated for 42 h with 100 μM mevalonic acid (control) or mevalonic acid plus 5 μM compactin (unloaded), 10 μM 20(S)-hydroxycholesterol [20(S)HC], 10 μM 22(R)-hydroxycholesterol [22(R)HC], or 10 μM lanosterol. Northern analysis was performed as described above.
