Table 2.
Phenotypes of zi/zi rats in Atrn-transgenic lines
| Line | Transgene
|
Number of N2 animals examined | Phenotypes
|
|||
|---|---|---|---|---|---|---|
| Name | Number of copy | Symptoms | CNS pathology | Coat color | ||
| TK320-14 | CAG+M | ∼1 | 6 | Normal | Normal | Agouti |
| TK320-27 | CAG+M | ∼1 | 10 | Normal | Normal | Agouti |
| TK322-43 | MMT+M | ∼1 | 8 | Normal | Normal | Agouti |
| TK322-48 | MMT+M | ∼1 | 8 | Normal | Normal | Agouti |
| TK328-73 | MMT+S | ∼100 | 5 | Tremor, paresis | Vacuolation, hypomyelination | Mahogany |
| TK328-76 | MMT+S | ∼1 | 5* | Tremor, paresis | Vacuolation, hypomyelination | Mahogany |
*
N3 animals were included.