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ATP synthesis rate and Δψ were measured in permeabilized lymphocytes from both 10 probands carrying the mtDNA T8993G mutation and 12 healthy and age-matched volunteers as controls. (A) The correlation between ATP synthesis rate and mutation load (r2=0.85). (B) The correlation between Δψm and mutation load (r2=0.72). (C) The correlation between ATP synthesis rate and Δψm (r2=0.83).
