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. 2006 May 15;396(Pt 2):363–369. doi: 10.1042/BJ20051478

Figure 5. S180 enhances the TEA block under low [K+]o.

Figure 5

(A) Representative Kv2.1 currents recorded under normal (4 mM) or decreased (1 mM) [K+]o, in the absence (left panel) or presence of 10 mM TEA (right panel) with either GST or S180 in the pipette. Currents were elicited as described in Figure 1(A) with external 140 mM NaCl and 4 mM KCl (140 mM KCl in the pipette), or (B) and (C) under symmetrical 140 mM NaCl with decreased [K+]o (1 mM). (D) Dose-dependent blockade of Kv2.1 current measured under normal [K+]o (4 mM) (IC50 6.8±0.9 mM), decreased [K+]o (1 mM) (IC50>100 mM), or when internally dialysed with 1 pM S180 in the presence of 1 mM [K+]o (IC50 7.9±1.5 mM). n=5 or 6 cells.