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. 2006 May 18;116(6):1633–1641. doi: 10.1172/JCI25702

Figure 1. Airway responses following i.n. OVA challenge in a mouse model of chronic asthma.

Figure 1

(A) Penh responses to aerosolized methacholine 24 hours after the eighth OVA or PBS challenge. (B) Penh measured 1 hour before and 1, 3, 6, 9, 12, 15, 18, 21, and 24 hours after the ninth OVA or PBS challenge. (C) Changes in RL and (D) lung Cdyn after aerosolized methacholine administered 24 hours after the ninth OVA or PBS challenge. Data are from OVA-sensitized/challenged WBB6F1-Kit+/+ (filled circles), WBB6F1-KitW/W-v(open circles), and WBB6F1-Kit+/+ BMCMCs→KitW/W-v (gray circles) mice and PBS-treated WBB6F1-Kit+/+ (filled squares), WBB6F1-KitW/W-v (open squares), and WBB6F1-Kit+/+ BMCMCs→KitW/W-v (gray squares) mice. *P < 0.05 versus corresponding PBS-treated controls; †P < 0.05 versus OVA-sensitized/challenged KitW/W-v group. n = 8 per group (A and B); n = 4 per group (C and D).