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. 2001 Jan 16;98(2):620–624. doi: 10.1073/pnas.98.2.620

Figure 4.

Figure 4

Inhibition of MDA-MD-435 breast carcinoma growth by anastellin, sFN, and sFBG. Nude mice bearing s.c. tumors from MDA-MB-435 breast carcinoma cells were used in a treatment experiment similar to the one shown in Fig. 3. The doses per injection were as follows: anastellin, 600 μg; sFN, 100 μg of fibronectin mixed with 300 μg of anastellin; sFBG, 500 μg of fibrinogen mixed with 300 μg of anastellin; III-11C, 600 μg. Six mice were used per group. The tumors were significantly smaller at the end of the experiment in the mice treated with anastellin (P < 0.01), sFN (P < 0.001), or sFBG (P < 0.001) than in the mice treated with vehicle alone or with III-11C.