Table 1.
Effects of smoking placebo versus marijuana on mean±SEM subjective, autonomic, and memory task performance variables. Asterisks in post-smoking intervals 2–5 denote that the change from baseline interval 1 is significantly different between the placebo and marijuana conditions. Response times in ms; WM working memory; WR word recognition
| Recording interval
|
1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Hours since smoking | Pre-smoking | 0:20 | 1:20 | 2:20 | 3:20 | |
| Highness | Placebo | 2±1 | 6±2 | 3±1 | 2±1 | 2±1 |
| Rating | Marijuana | 1±0 | 60±12** | 53±10** | 33±7** | 20±6** |
| Heart | Placebo | 66±4 | 69±5 | 69±4 | 68±4 | 64±3 |
| Rate | Marijuana | 69±5 | 104±6** | 80±3 | 72±4 | 75±4 |
| WM low load | Placebo | 98.0±0.7 | 98.4±0.5 | 97.4±0.6 | 98.2±0.6 | 97.8±0.7 |
| % Correct | Marijuana | 98.4±0.5 | 99.0±0.4 | 98.8±0.4 | 95.4±2.4 | 98.4±0.7 |
| WM high load | Placebo | 96.8±1.0 | 97.4±0.5 | 98.2±0.7 | 98.0±0.8 | 97.2±1.0 |
| % Correct | Marijuana | 96.0±1.7 | 94.4±1.8* | 94.8±1.8 | 95.6±1.4 | 92.6±1.4 |
| WM low load | Placebo | 418±27 | 403±23 | 409±22 | 388±14 | 396±16 |
| Response time | Marijuana | 415±17 | 475±26* | 468±21* | 457±21 | 416±13 |
| WM high load | Placebo | 503±35 | 486±33 | 484±35 | 490±37 | 480±36 |
| Response time | Marijuana | 496±29 | 600±37** | 592±36* | 561±35 | 503±29 |
| WR old words | Placebo | 77.0±4.5 | 86.8±3.9 | 86.8±3.2 | 83.0±3.6 | 82.3±3.6 |
| % Correct | Marijuana | 79.5±3.5 | 77.8±4.5 | 84.3±3.4 | 84.3±3.2 | 82.5±3.4 |
| WR new words | Placebo | 84.8±2.5 | 85.5±2.5 | 84.3±3.5 | 84.5±3.8 | 86.3±2.6 |
| % Correct | Marijuana | 87.2±3.1 | 71.8±4.4 | 69.8±4.6** | 64.5±5.3* | 72.3±4.4 |
| WR old words | Placebo | 792±30 | 758±33 | 741±30 | 725±29 | 742±36 |
| Response time | Marijuana | 869±39 | 847±34 | 831±35 | 786±31 | 769±30 |
| WR new words | Placebo | 811±27 | 755±20 | 757±25 | 782±23 | 778±33 |
| Response time | Marijuana | 831±16 | 953±48** | 904±46 | 870±30 | 818±25 |
*
P < 0.05
**
P< 0.01