Table 1.

Major enriched categories for genes with ≥ 250 bp and ≥ 100 bp R•Y

Combined Rank	Category (term—pathway)	P-value		Fold enrichment
		≥250 R•Y	≥100 R•Y	≥250 R•Y	≥100 R•Y
GO molecuar function
10	Ion channel activity	1.95E−05	5.92E−09	4.4	2.2
12	Protein binding	3.14E−03	6.25E−15	1.7	1.6
20	Glutamate receptor activity	6.11E−04	1.92E−07	10.3	4.3
GO biological process
5	Cell adhesion	1.11E−04	3.36E−12	3.4	2.2
7	Cell communication	2.19E−04	5.24E−15	1.6	1.4
15	Transmission of nerve impulse	1.83E−04	5.24E−08	5.1	2.5
GO cellular component
2	Membrane	2.78E−06	2.46E−14	1.6	1.3
15	Synapse	2.18E−02	7.69E−05	5.0	2.8
19	Extracellular matrix	4.96E−02	1.33E−08	2.3	2.2
Pfam family
2	Fibronectin type III	2.84E−05	1.43E−12	5.1	2.8
15	C-cadherin	7.76E−05	3.14E−05	17.0	4.3
17	C2	1.17E−04	3.95E−05	5.4	2.1
PIR family
3	α-catenin	3.55E−04	1.20E−03	60.4	9.4
11	Cadherin	1.81E−02	4.04E−04	9.5	4.0
KEGG pathway
5	Neuroactive ligand–receptor interaction	7.06E−03	2.52E−03	2.9	1.5
6	Phosphatidylinositol signaling system	2.30E−02	1.87E−05	4.8	2.6
7	Cholera—infection	1.26E−02	3.39E−03	6.0	2.2
Protein interaction partners
22	DLG4	7.98E−04	2.06E−03	45.1	6.1
23	RAC1	8.34E−03	9.78E−04	7.1	2.4
Disease association
4	Schizophrenia	5.23E−03	2.33E−03	7.5	2.6

Combined Rank, sum of the two categories ranks from Supplementary Tables 2 and 3; categories with one entry were excluded; when more than one category with largely redundant gene entries was present, only one was chosen.