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Effect of the BRCA1 452–1079 amino acids fragment on WRN helicase and exonuclease activities. (A) WRN helicase activity was measured as described in Figure 4 using a 22 bp forked duplex substrate. (B) WRN exonuclease activity was measured on a 34 bp forked duplex substrate. Purified WRN was pre-incubated with BRCA1 452–1079 amino acids at the indicated concentrations in 10 µl assay buffer. The mean percent strand displacement or digestion (n = 2) on the substrate is shown.
